Trk B (Phospho-Tyr706/Tyr707) Antibody

Catalog Number:

11758

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q16620;
NCBI Gene#: 4915;
NCBI Protein#: NP_001018074.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 706/tyrosine 707 (T-D-Y(p)-Y(p)-R-V)derived from Human Trk B.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of Trk B only when phosphorylated at tyrosine 706 and tyrosine 707.

Applications:

IHC

Background:

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Nakagawara A., Genomics 25:538-546(1995).
Shelton D.L., J. Neurosci. 15:477-491(1995).
Stoilov P., Biochem. Biophys. Res. Commun. 290:1054-1065(2002).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF