MER/SKY (Phospho-Tyr749/681) Antibody

Catalog Number:

11740

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q12866/Q06418;
NCBI Gene#: 10461/7301;
NCBI Protein#: NP_006334.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 749/681(K-I-Y(p)-S-G) derived from Human MER/SKY .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of MER/SKY only when phosphorylated at tyrosine 749/681.

Applications:

WB IHC

Background:

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Graham D.K., Cell Growth Differ. 5:647-657(1994).
Gal A., Nat. Genet. 26:270-271(2000).
Hillier L.W., Nature 434:724-731(2005).

References:

appl_detail:

Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Datasheet PDF