IRAK1 (Phospho-Ser376) Antibody

Catalog Number:

11735

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P51617;
NCBI Gene#: 3654;
NCBI Protein#: NP_001560.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 376(Q-S-S(p)-M-V) derived from Human IRAK1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of IRAK1 only when phosphorylated at serine 376.

Applications:

IHC

Background:

IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B.

Cao Z., Science 271:1128-1131(1996).
Reichwald K., Mamm. Genome 11:182-190(2000).
Jensen L.E., J. Biol. Chem. 276:29037-29044(2001).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF