STMN1 (Phospho-Ser63) Antibody

Catalog Number:

11722

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P16949;
NCBI Gene#: 3925;
NCBI Protein#: NP_005554.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 63(R-K-S(p)-H-E) derived from Human STMN1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of STMN1 only when phosphorylated at serine 63.

Applications:

WB IHC

Background:

This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Alternatively spliced transcript variants encoding the same protein have been identified.

Zhu X.-X., J. Biol. Chem. 264:14556-14560(1989).
Maucuer A., FEBS Lett. 264:275-278(1990).
Melhem R.F., J. Biol. Chem. 266:17747-17753(1991).

References:

appl_detail:

Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Datasheet PDF