IGF1R (Phospho-Tyr1346) Antibody

Catalog Number:

11716

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P08069;
NCBI Gene#: 3480;
NCBI Protein#: NP_000866.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 1346(Q-P-Y(p)-A-H) derived from Human IGF1R .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346.

Applications:

IHC

Background:

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

Ullrich A., EMBO J. 5:2503-2512(1986).
Abbot A.M., J. Biol. Chem. 267:10759-10763(1992).
The MGC Project Team;Genome Res. 14:2121-2127(2004).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF