Trk A (Phospho-Tyr791) Antibody

Catalog Number:

11646

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P04629;
NCBI Gene#: 4914;
NCBI Protein#: NP_002520.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 791 (P-V-Y(p)-L-D) derived from Human Trk A.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 791.

Applications:

IHC

Background:

Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.

Tina Garofalo, J. Biol. Chem., Dec 1998; 273: 35153.
Jan Grimm, J. Cell Biol., Jul 2001; 154: 345.
Jose L. Tomsig, J Androl, May 2006; 27: 348 - 357.
VI Shifrin and BG Neel J. Biol. Chem., Dec 1993; 268: 25376 - 25384

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF