RANKL Antibody

Catalog Number:

48332

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:O14788

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

peptide

Purification:

Immunogen affinity purified

Specificity/Sensitivity:

Applications:

WB, IP, IF, IHC(P)

Background:

Members of the tumor necrosis factor (TNF) receptor superfamily interact with signaling molecules of the TNF receptor-associated factor (TRAF) family to activate the NF?B and JNK pathways. RANK (receptor activator of NF?B) is a member of the TNFR family identified on dendritic cells. This type I membrane receptor is expressed in a broad range of tissues. The C-terminus of RANK is required for RANK to bind TRAF2, 5 and 6, and it is also necessary for stimulating NF?B activation. The ligand for this receptor, RANKL (also designated TRANCE, OPGL or ODF), is a type II transmembrane protein expressed primarily in lymphoid tissues and T cell lines. RANKL appears to be an important regulator of T cells and osteoclasts.

References:

appl_detail:

WB: 1:100-1:1,000
IHC: 1:50-500

IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)

Datasheet PDF