EPS15 (Phospho-Tyr849) Antibody

Catalog Number:

11800

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P42566;
NCBI Gene#: 2060;
NCBI Protein#: NP_001972.1.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 849 (S-A-Y(p)-P-S) derived from Human Ephrin EPS15.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of EPS15 only when phosphorylated at tyrosine 849.

Applications:

WB

Background:

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Wong W.T., Oncogene 9:1591-1597(1994).
Bernard O.A., Oncogene 9:1039-1045(1994).

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF