Phospho-eIF2α-S51 Rabbit mAb

Catalog Number:

78270

Amount:

100μg

Price:

$318

Swiss-Prot No:

P05198

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Phospho-EIF2S1 (S51).

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF