Troponin I2 (TNNI2) Rabbit mAb

Catalog Number:

78267

Amount:

100μg

Price:

$318

Swiss-Prot No:

P48788

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Troponin I2 (Troponin I2 (TNNI2))

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IF

Background:

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

References:

appl_detail:

WB 1:500 - 1:2000
IF 1:50 - 1:200

Datasheet PDF