[KO Validated] Lamin A/C Rabbit mAb

Catalog Number:

78256

Amount:

100μg

Price:

$318

Swiss-Prot No:

P02545

Form of Antibody:

Storage/Stability:

Immunogen:

Recombinant protein of human Lamin A/C.

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IHC,IF,IP

Background:

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

References:

appl_detail:

WB 1:50000 - 1:200000
IHC 1:50 - 1:1000
IF 1:50 - 1:1000
IP 1:50 - 1:200

Datasheet PDF