[KO Validated] RB Rabbit mAb

Catalog Number:

77984

Amount:

100μg

Price:

$318

Swiss-Prot No:

P06400

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human RB

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB,IF

Background:

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000
IF 1:50 - 1:200

Datasheet PDF