NOX2/gp91phox Rabbit mAb

Catalog Number:

77187

Amount:

100μg

Price:

$318

Swiss-Prot No:

P04839

Form of Antibody:

Storage/Stability:

Immunogen:

A synthesized peptide derived from human NOX2/gp91phox .

Purification:

Affinity purification

Specificity/Sensitivity:

Applications:

WB

Background:

Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]

References:

appl_detail:

WB 1:500 - 1:2000

Datasheet PDF