CBS Antibody

Catalog Number:

49984

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#:P35520

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant protein within human CBS aa 400-550.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB,ICC

Background:

Strongly expressed in human liver and pancreas, with weaker expression in heart and brain, the cytoplasmic protein cystathionine b-synthase (CBS) operates in the first step of homocysteine transulfuration. CBS, which belongs to the cysteine synthase/cystathionine b-synthase family of proteins, catalyzes the formation of cystathionine from the thrombogenic amino acid homocysteine using pyridoxal phosphate cofactor. Allosteric activation by adenosyl-methionine regulates CBS activity. Deficiencies in CBS are assoc-iated with homocystinuria, a recessively inherited error in sulfur amino acid metabolism that affects many organs and tissues. Symptoms of homocytinuria include arteriosclerosis, thrombosis, dislocated optic lenses, mental retard-ation and skeletal abnormalities.

References:

appl_detail:

WB: 1:500-1:2,000

ICC: 1:50-1:100

Datasheet PDF