1-832-868-1888
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Catalog Number: |
49896 |
other_names: | CENP-C 1 antibody CENP-C antibody CENPC_HUMAN antibody CENPC1 antibody Centromere autoantigen C antibody Centromere autoantigen C1 antibody Centromere protein C 1 antibody Centromere protein C antibo |
Amount: |
100μg |
calculated_mw: | 107 kDa |
host_species: | Rabbit |
Price: |
$319 |
Swiss-Prot No: |
Swiss-Prot#:Q03188 |
Form of Antibody: |
1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Storage/Stability: |
|
Immunogen: |
Recombinant protein within human CENPC aa 400-600. |
Purification: |
ProA affinity purified |
Specificity/Sensitivity: |
|
Applications: |
WB,ICC,IF,IHC,FC,IP |
Background: |
A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The evolutionarily conserved Centromere Protein-C, CENP-C, is a kinetochore assembly protein. CENP-C is located on the fibers of the kinetochore and constitutes a kinetochore organizing center that tightly associates with DNA. CENP-C is necessary for the formation of a functional centromere, which indicates that CENP-C is important for mitotic progression. In addition, CENP-C is lost from centromeres during herpes simplex virus 1 infection, causing substantial structural changes in the kinetochore, which suggests that the structure of CENP-C is regulated during the cell cycle. |
References: |
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appl_detail: |
WB: 1:500-1:2,000 |
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