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CENPC Antibody

Catalog Number:

49896
other_names: CENP-C 1 antibody
CENP-C antibody
CENPC_HUMAN antibody
CENPC1 antibody
Centromere autoantigen C antibody
Centromere autoantigen C1 antibody
Centromere protein C 1 antibody
Centromere protein C antibo

Amount:

100μg
calculated_mw: 107 kDa
host_species: Rabbit

Price:

$319

Swiss-Prot No:

Swiss-Prot#:Q03188

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant protein within human CENPC aa 400-600.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB,ICC,IF,IHC,FC,IP

Background:

A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The evolutionarily conserved Centromere Protein-C, CENP-C, is a kinetochore assembly protein. CENP-C is located on the fibers of the kinetochore and constitutes a kinetochore organizing center that tightly associates with DNA. CENP-C is necessary for the formation of a functional centromere, which indicates that CENP-C is important for mitotic progression. In addition, CENP-C is lost from centromeres during herpes simplex virus 1 infection, causing substantial structural changes in the kinetochore, which suggests that the structure of CENP-C is regulated during the cell cycle.

References:

appl_detail:

WB: 1:500-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200
IP: 1:10-1:50
FC: 1:50-1:200

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