hnRNP Q Antibody

Catalog Number:	49889
other_names:	cytoplasmic RNA-interacting protein antibody dJ3J17.2 antibody Glycine and tyrosine rich RNA binding protein antibody Glycine- and tyrosine-rich RNA-binding protein antibody GRY RBP antibody GRY-RBP antibody
Amount:	100μg
calculated_mw:	70 kDa
host_species:	Rabbit
Price:	$319
Swiss-Prot No:	Swiss-Prot#:O60506
Form of Antibody:	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Storage/Stability:
Immunogen:	Recombinant protein to C-terminal human hnRNP Q.
Purification:	ProA affinity purified
Specificity/Sensitivity:
Applications:	WB,ICC,IF,IHC
Background:	Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) is involved in RNA processing and is necessary for efficient pre-mRNA splicing. hnRNP is widely expressed and developmentally regulated. hnRNP Q interacts with survival motor neuron protein (SMN). Loss of function of SMN results in spinal muscular atrophy, a common neurodegenerative disease. The most common deletion in SMN genes disrupts the interaction between SMN and hnRNP Q. hnRNP Q is upregulated after midnight, and this upregulation correlates with an abrupt decline in AANAT, the key enzyme in melatonin synthesis. Rhythmic AANAT mRNA degradation mediated in part by hnRNP Q implicates this enzyme in the regulation of circadian oscillation.
References:
appl_detail:	WB: 1:500-1:2,000 IHC: 1:50-1:200 ICC: 1:50-1:200
	Datasheet PDF

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