KLHL22 Antibody

Catalog Number:	48480
other_names:	2610318I18Rik antibody kelch-like 22 antibody kelch-like family member 22 antibody Kelch-like protein 22 antibody KELCHL antibody KLH22_HUMAN antibody Klhl22 antibody RGD1306288 antibody
Amount:	100μg
calculated_mw:	72 kDa
host_species:	Mouse
Price:	$529
Swiss-Prot No:	Swiss-Prot#:Q53GT1
Form of Antibody:	1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.
Storage/Stability:
Immunogen:	Recombinant protein
Purification:	ProA affinity purified
Specificity/Sensitivity:
Applications:	WB,ICC
Background:	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
References:
appl_detail:	WB: 1:500 ICC: 1:100-1:500
	Datasheet PDF

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