EIF2A Antibody

Catalog Number:

48432

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot#:Q9BY44

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

Recombinant protein

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, ICC, IHC, FC

Background:

eIF2A (eukaryotic translation initiation factor 2A), also known as CDA02, MSTP004 or MSTP089, is a 585 amino acid protein that contains three WD repeats. Expressed ubiquitously with highest expression in heart, brain, pancreas and placenta, eIF2A functions as a translation initiation factor that binds Met-tRNA and directs it to 40S ribosomal subunits. Present in the early steps of protein synthesis, eIF2A controls the binding of Met-tRNA to 40S ribosomal subunits in a codon-dependent manner, in contrast to the eIF2 complex which accomplishes the same task in a GTP-dependent manner. In addition to its role in transcription initiation, eIF2A may also act to negatively regulate the expression of specific proteins, suggesting a possible role as a transcriptional repressor. eIF2A exists as two isoforms due to alternative splicing events.

References:

appl_detail:

WB: 1:500-1:2,000
IHC: 1:50-1:200
ICC: 1:50-1:200

FC: 1:50-1:100

Datasheet PDF