Citrate synthase Antibody

Catalog Number:

48284

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot#:O75390

Form of Antibody:

1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage/Stability:

Immunogen:

An epitope mapping between amino acids 259-292 of citrate synthase of human origin.

Purification:

ProA affinity purified

Specificity/Sensitivity:

Applications:

WB, IP, IF, IHC(P)

Background:

Citrate synthase (CS) is a 466 amino acid mitochondrial matrix protein that functions as the first and rate-limiting enzyme of the tricarboxylic acid cycle. Essential in mitochondrial respiration and involved in the conversion of glucose to lipid, citrate synthase is found the great majority of cells that are capable of oxidative metabolism. The gene encoding citrate synthase maps to human chromosome 12q13.3, which is transcribed into two alternatively spliced variants designated CSa and CSb. Human chromosome 12 encodes over 1,100 genes, comprises approximately 4.5% of the human genome and is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and trisomy 12p, which causes facial developmental defects and seizure disorders.

References:

appl_detail:

WB: 1:100-1:1,000
IHC: 1:50-500

IP: 1-2 μg per 100-500 μg of total protein(1 ml of cell lysate)

Datasheet PDF