Cardiac Troponin I Monoclonal Antibody

Catalog Number:

42040

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot#: P19429

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant Human Cardiac Troponin I protein

Purification:

protein G purifed

Specificity/Sensitivity:

Reacts equally with free cardiac troponin I and cardiac troponin I forming complexes with other troponin components. Not affected by heparin, phosphorylation and oxidation. No cross-reactivity with skeletal muscle troponin I.

Applications:

WB

Background:

Troponin I is part of a heteromeric complex playing an important role in the regulation of skeletal and cardiac muscle contraction. It consists of three subunits, troponin I (TnI), troponin T (TnT) and troponin C (TnC). Each subunit is responsible for part of troponin complex function. TnI inhibits ATPase activity of acto myosin and TnT and TnI are present in cardiac muscles in different forms than in skeletal muscles. Only one tissue specific isoform of TnI is described for cardiac muscle tissue (cTnI) and this is expressed only in myocardium.

References:

[1] Apple FS.Tissue specificity of cardiac troponin I,cardiac troponin T and creatine Kinase-MB[J].Clin Chim Acta,1999,284:151-159 [2] Stein PD, Janjua M, Matta F, Pathak PK, Jaweesh F, Alrifai A, Chughtai HL. Prognosis based on creatine kinase isoenzyme

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF