Myoglobin Monoclonal Antibody

Catalog Number:

42039

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot#: P02144

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant Human Myoglobin protein

Purification:

protein G purifed

Specificity/Sensitivity:

specific for Human Myoglobin denatured and native forms

Applications:

WB

Background:

Myoglobin is a small heme containing protein (153 amino acid residues, molecular weight (w/o heme) 17053 Da and theoretical pI=7.29) responsible for the oxygen deposition in muscle tissues. Only one form of myoglobin is expressed in cardiac and skeletal muscles. Myoglobin is known as a marker of myocardial damage and it has been used for more than three decades. Nowadays it still is very commonly used in clinical practice as an early marker of AMI. It appears in patient's blood 1 to 3 hours after onset of the symptoms, reaching peak level within 8 to 12 hours. Myoglobin is not so cardiac specific as cTnI or cTnT. Because of high myoglobin concentration in skeletal muscle tissue, even minor skeletal muscle injury results in the significant increase of myoglobin concentration in blood. Thus myoglobin is used together with cTnI or cTnT in clinical practise for better specificity in AMI diagnosis.

References:

[1] Karabay O, Tuna N, Ogutlu A, Gozdas HT.High ferritin and myoglobin level in legionella pneumonia: a case report and review of literature. Indian J Pathol Microbiol. 2011 Apr-Jun;54(2):381-3.[2] Liu M, Hou M, Liu LP, Zhang CX, Zhao CY, Ma CJ, Zhong S

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF