Bcl-2-like protein 1 Monoclonal Antibody

Catalog Number:

42016

Amount:

100μg

Price:

$529

Swiss-Prot No:

Swiss-Prot#: Q07817

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant Human Bcl-2-like protein 1 protein

Purification:

protein G purifed

Specificity/Sensitivity:

specific for Human Bcl-2-like protein 1 denatured and native forms

Applications:

WB IHC

Background:

Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.

References:

"bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." Boise L.H., Gonzalez-Garcia M., Postema C.E., Ding L., Lindsten T., Turka L.A., Mao X., Nunez G., Thompson C.B. Cell 74:597-608(1993) [PubMed] [Europe PMC] [Abstract]

appl_detail:

Western blotting: 1:500 - 1:1000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF