ZNF217 Antibody

Catalog Number:

42875

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: O75362
Gene ID: 7764

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein of human ZNF217

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total ZNF217 protein.

Applications:

IHC

Background:

ZNF217, also known as ZABC1, is a zinc finger protein belonging to the Kr¨¹ppel C2H2-type zinc-finger protein family. It localizes to the nucleus and may play a role in transcriptional repression of a variety of genes through the recruitment of co-repressor complexes containing proteins such as CtBP, HDAC1 and HDAC2. In addition, ZNF217 participates in cell differentiation and appears to function as an oncogene. Expression of ZNF217 is amplified in various tumors and overexpression of the protein can attenuate apoptotic signals and lead to epithelial cell immortalization.Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.

References:

appl_detail:

Immunohistochemistry: 1:25-1:100

Datasheet PDF