Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase Polyclonal Antibody

Catalog Number:

42601

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q99640

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase polyclonal antibody.

Applications:

IHC

Background:

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

References:

[1]Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity.Booher R.N., Holman P.S., Fattaey A.J. Biol. Chem. 272:22300-22306(1997) [2]The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes t

appl_detail:

Immunohistochemistry: 1:20 - 1:200

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