Midkine Polyclonal Antibody

Catalog Number:

42524

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P21741

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Midkine protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Midkine polyclonal antibody.

Applications:

IHC

Background:

Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development

References:

[1] "A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse."Tsutsui J., Uehara K., Kadomatsu K., Matsubara S., Muramatsu T.Biochem. Biophys. Res. Commun. 176:792-797(1991) [2] "Cloning, ch

appl_detail:

Immunohistochemistry: 1:20 - 1:200

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