Receptor tyrosine-protein kinase erbB-2 Polyclonal Antibody

Catalog Number:

42510

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P04626

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Receptor tyrosine-protein kinase erbB-2 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Receptor tyrosine-protein kinase erbB-2 polyclonal antibody.

Applications:

IHC

Background:

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

References:

[1] "Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor." Yamamoto T., Ikawa S., Akiyama T., Semba K., Nomura N., Miyajima N., Saito T., Toyoshima K.Nature 319:230-234(1986) [2] "Tyrosine kinase receptor with

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF