Angiogenin Polyclonal Antibody

Catalog Number:

42438

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P03950

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Angiogenin protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Angiogenin polyclonal antibody.

Applications:

IHC

Background:

May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.

References:

[1]Sequence of the cDNA and gene for angiogenin, a human angiogenesis factor.Kurachi K., Davie EW., Strydom D.J., Riordan J.F., Vallee B.L.Biochemistry 24:5494-5499(1985) [2]Diversifying selection of the tumor-growth promoter angiogenin in primate evol

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF