Acid-sensing ion channel 3 Polyclonal Antibody

Catalog Number:

42434

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UHC3

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Acid-sensing ion channel 3 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Acid-sensing ion channel 3 polyclonal antibody.

Applications:

WB IHC

Background:

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties.

References:

[1] Molecular cloning of a DEG/ENaC sodium channel cDNA from human testis.Ishibashi K., Marumo F. Biochem. Biophys. Res. Commun. 245:589-593(1998) [2]Identification, functional expression and chromosomal localisation of a sustained human proton-gated

appl_detail:

Western blotting: 1:500 - 1:1000

Datasheet PDF