Glutaminyl-peptide cyclotransferasePolyclonal Antibody

Catalog Number:

42302

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q16769

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Glutaminyl-peptide cyclotransferase protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Glutaminyl-peptide cyclotransferasepolyclonal antibody.

Applications:

WB

Background:

Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.

References:

[1]Molecular cloning, sequence analysis and expression of human pituitary glutaminyl cyclase.Song I., Chuang C.Z., Bateman R.C. Jr.J. Mol. Endocrinol. 13:77-86(1994)[2]Complete sequencing and characterization of 21,243 full-length human cDNAs.Ota T., Su

appl_detail:

Western blotting: 1:500 - 1:1000

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