KITLG Polyclonal Antibody

Catalog Number:

42231

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P21583

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Kit ligand protein (26-214aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total KITLG polyclonal antibody.

Applications:

WB

Background:

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

References:

[1]"Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation."Wang Z.-Q., Si L., Tang Q., Lin D., Fu Z., Zhang J., Cui B., Zhu Y., Kong X., Deng M., Xia Y., Xu H., Le W., Hu L., Kong X.Am. J. Hum. Genet. 8

appl_detail:

Western blotting: 1:500 - 1:2000

Datasheet PDF