Beta-adrenergic receptor kinase 1 Polyclonal Antibody

Catalog Number:

42189

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P25098

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant human Beta-adrenergic receptor kinase 1 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Beta-adrenergic receptor kinase 1 polyclonal antibody.

Applications:

IHC

Background:

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.

References:

[1] cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.Benovic J.L., Stone W.C., Huebner K., Croce C., Caron M.G., Lefkowitz R.J.FEBS Lett. 283:122-126(1991) [2] High expression of beta-adrenergic receptor kinase in

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF