CLIC4 Polyclonal Antibody

Catalog Number:

42126

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9Y696

Form of Antibody:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage/Stability:

Immunogen:

Recombinant human Chloride intracellular channel protein 4 protein (1-253aa)

Purification:

Antigen Affinity Purified

Specificity/Sensitivity:

The antibody detects endogenous level of total CLIC4 polyclonal antibody.

Applications:

WB IHC

Background:

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis .

References:

[1]"Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals." Li Y., Li D., Zeng Z., Wang D.Biochem. Biophys. Res. Commun. 343:1272-1278(2006). [2]"Crystal structure of the soluble form of the redox-regulated c

appl_detail:

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:20 - 1:200

Datasheet PDF