Apoptosis regulator Bcl-2 Polyclonal Antibody

Catalog Number:

42081

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P10417

Form of Antibody:

Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage/Stability:

Immunogen:

Recombinant mouse Apoptosis regulator Bcl-2 protein

Purification:

Caprylic Acid Ammonium Sulfate Precipitation purified

Specificity/Sensitivity:

The antibody detects endogenous level of total Apoptosis regulator Bcl-2 polyclonal antibody.

Applications:

IHC

Background:

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

References:

[1] "Molecular analysis of mbcl-2: structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma."Negrini M., Silini E., Kozak C., Tsujimoto Y., Croce C.M.Cell 49:455-463(1987) [2] "Isolation

appl_detail:

Immunohistochemistry: 1:20 - 1:200

Datasheet PDF