BRAP Monoclonal Antibody

Catalog Number:

27218

Amount:

100μg

Price:

$369

Swiss-Prot No:

Uniprot: Q7Z569

Gene ID: 8315

Form of Antibody:

Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Purified recombinant human BRAP protein fragments expressed in E.coli.

Purification:

Affinity purified

Specificity/Sensitivity:

This antibody detects endogenous levels of BRAP and does not cross-react with related proteins.

Applications:

WB

Background:

Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.

References:

appl_detail:

Western blotting: 1:1000

Datasheet PDF