AMPK beta 1 Monoclonal Antibody

Catalog Number:

27201

Amount:

100μg

Price:

$369

Swiss-Prot No:

Uniprot: Q9Y478

Gene ID: 5564

Form of Antibody:

Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Purified recombinant human AMPK beta 1 protein fragments expressed in E.coli.

Purification:

Affinity purified

Specificity/Sensitivity:

This antibody detects endogenous levels of AMPK beta 1 and does not cross-react with related proteins.

Applications:

WB ICC IP IHC

Background:

 Non-catalytic subunit of AMP-activated protein kinase (AMPK),an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism.In response to reduction of intracellular ATP levels,AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein,carbohydrate and lipid biosynthesis,as well as cell growth and proliferation.AMPK acts via direct phosphorylation of metabolic enzymes,and by longer-term effects via phosphorylation of transcription regulators.Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton;probably by indirectly activating myosin.Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles,via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1,PRKAG2 or PRKAG3).

References:

appl_detail:

Western blotting: 1:1000

Immunocytochemistry: 1:100

Datasheet PDF