DR5 Monoclonal Antibody

Catalog Number:	27200
other_names:	Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L;
Amount:	100μg
calculated_mw:
host_species:	Mouse
Price:	$369
Swiss-Prot No:	Uniprot: O14763 Gene ID: 8795
Form of Antibody:	Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Storage/Stability:
Immunogen:	Purified recombinant human TNFRSF10B protein fragments expressed in E.coli.
Purification:	Affinity purified
Specificity/Sensitivity:	This antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins.
Applications:	WB ICC
Background:	Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Essential for ER stress-induced apoptosis.
References:
appl_detail:	Western blotting: 1:500-1:2000 Immunocytochemistry: 1:100
	Datasheet PDF

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