Smad2 Monoclonal Antibody

Catalog Number:	27195
other_names:	hMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2;
Amount:	100μg
calculated_mw:
host_species:	Mouse
Price:	$369
Swiss-Prot No:	Uniprot: Q15796 Gene ID: 4087
Form of Antibody:	ascites
Storage/Stability:
Immunogen:	Purified recombinant human SMAD2 protein fragments expressed in E.coli.
Purification:
Specificity/Sensitivity:	This antibody detects endogenous levels of SMAD2 and does not cross-react with related proteins.
Applications:	WB ICC
Background:	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
References:
appl_detail:	Western blotting: 1:500 Immunocytochemistry: 1:100
	Datasheet PDF

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