TORC1 Monoclonal Antibody

Catalog Number:

27183

Amount:

100μg

Price:

$369

Swiss-Prot No:

Uniprot: Q6UUV9

Gene ID: 23373

Form of Antibody:

ascites

Storage/Stability:

Immunogen:

Purified recombinant human CRTC1 protein fragments expressed in E.coli.

Purification:

Specificity/Sensitivity:

This antibody detects endogenous levels of CRTC1 and does not cross-react with related proteins.

Applications:

WB ICC

Background:

 Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway,being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene,StAR.Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses.May be required for dendritic growth of developing cortical neurons.

References:

appl_detail:

Western blotting: 1:2000 

Immunocytochemistry: 1:200

Datasheet PDF