CSK Monoclonal Antibody

Catalog Number:

27181

Amount:

100μg

Price:

$369

Swiss-Prot No:

Uniprot: P41240

Gene ID: 1445

Form of Antibody:

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.

Storage/Stability:

Immunogen:

Purified recombinant human CSK protein fragments expressed in E.coli.

Purification:

Affinity purified

Specificity/Sensitivity:

This antibody detects endogenous levels of CSK and does not cross-react with related proteins.

Applications:

WB ICC

Background:

 Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.

References:

appl_detail:

Western blotting: 1:1000

Immunocytochemistry: 1:50

Datasheet PDF