GRB2 Monoclonal Antibody

Catalog Number:	27180
other_names:	Abundant SRC homology; Adapter protein GRB2; ASH; Ash protein; EGFRBP GRB2; Epidermal growth factor receptor binding protein; Epidermal growth factor receptor binding protein GRB2; GRB 2; GRB2 adapter protein; Grb2; GRB2_HUMAN; Grb3 3;
Amount:	100μg
calculated_mw:
host_species:	Mouse
Price:	$369
Swiss-Prot No:	Uniprot: P62993 Gene ID: 2885
Form of Antibody:	Ascites
Storage/Stability:
Immunogen:	Purified recombinant human GRB2 protein fragments expressed in E.coli.
Purification:
Specificity/Sensitivity:	This antibody detects endogenous levels of GRB2 and does not cross-react with related proteins.
Applications:	WB
Background:	Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
References:
appl_detail:	Western blotting: 1:500
	Datasheet PDF

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