HP1-gamma Monoclonal Antibody

Catalog Number:	27171
other_names:	CBX 3; CBX3; CBX3_HUMAN; Chromobox homolog 3 (HP1 gamma homolog, Drosophila); Chromobox homolog 3; Chromobox protein homolog 3; GAMMA; HECH; Heterochromatin like protein 1; Heterochromatin protein 1 homolog gamma; Heterochromatin protein HP1 gamma
Amount:	100μg
calculated_mw:
host_species:	Mouse
Price:	$369
Swiss-Prot No:	Uniprot: Q13185 Gene ID: 11335
Form of Antibody:	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Storage/Stability:
Immunogen:	Purified recombinant human HP1-gamma protein fragments expressed in E.coli.
Purification:	Affinity purified
Specificity/Sensitivity:	This antibody detects endogenous levels of HP1-gamma and does not cross-react with related proteins.
Applications:	WB ICC IP IHC
Background:	Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
References:
appl_detail:	Western blotting: 1:1000 Immunocytochemistry: 1:200
	Datasheet PDF

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