Mouse anti-Human CD86, FITC Conjugated mAb

Catalog Number:

28206

Amount:

100μg

Price:

$529

Swiss-Prot No:

Form of Antibody:

Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA

Storage/Stability:

Immunogen:

Purification:

Specificity/Sensitivity:

Applications:

FC

Background:

 CD86 also known as B7-2,is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors.It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86,along with CD80/B7-1.is an important accessory molecule in T cell costimulation via it's interaciton with CD28 and CD152/CTLA4.Since CD86 has rapid kinetics of induction.it is believed to be the major CD28 ligand expressed early in the immune response.it is also found on malignant Hodgkin and Reed Sternberg(HRS) cells in Hodgkin's disease.

 

1. Knapp, W et al., eds. (1989)  Leucocyte Typing IV: White Cell Differentiation Antigens, Oxford University Press, New York.

2. Lanier LL. et al. ( 1991)  J. Immunol. 146:4421-4426.

3. Campbell, JJ et al. (2001)  J. Immunol. 166:6477-6482.

4. Cooper MD et al. (2001)  Trends in Immunol. 22:633-640.

5. GalandriniR et al. (2002)  Blood. 100:4581-4589.

References:

appl_detail:

Vol.per.Test: 10 μl/Test

Notice: This reagent has been pre-diluted for use at recommended volume per test in flow cytometry analysis. Typically add 10ul of this reagent to 100μl of experimental sample with 1 X 106 cells per test. Please refer to the detailed protocol when you perform a test.

Datasheet PDF