Mouse anti-Human CD14, Purified mAb

Catalog Number:

28050

Amount:

100μg

Price:

$529

Swiss-Prot No:

Form of Antibody:

Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide

Storage/Stability:

Immunogen:

Purification:

Specificity/Sensitivity:

Applications:

FC

Background:

 4AW4 reacts with CD14, a 53-55 kDa molecule. CD14 is a human high affinity cell-surface receptor for complexes of lipopolysaccharide (LPS-endotoxin) and serum LPS-binding protein (LPB). CD14 antigen has a strong presence on the surface of monocytes/macrophages, is weakly expressed on granulocytes, but not expressed by myeloid progenitor cells. CD14 functions as a receptor for endotoxin; when the monocytes become activated they release cytokines such as TNF, and up-regulate cell surface molecules including adhesion molecules.This clone is cross reactive with non-human primate.

 

1.  Knapp, W et al., eds. (1989) Leucocyte Typing IV : White Cell Differentiation Antigens, Oxford University Press, New York.

2.  Makgoba, MW et al., (1988) Nature 331: 86-88

3.  Boyd. AW et al. (1989) Blood  73: 1896-1903

References:

appl_detail:

Notice: This reagent has been pre-diluted for use at recommended volume per test in flow cytometry analysis. Typically add 10ul of this reagent to 100μl of experimental sample with 1 X 106 cells per test. Please refer to the detailed protocol when you perform a test.

Datasheet PDF