Mouse anti-Human CD11b, FITC Conjugated mAb

Catalog Number:

28042

Amount:

100μg

Price:

$529

Swiss-Prot No:

Form of Antibody:

Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA

Storage/Stability:

Immunogen:

Purification:

Specificity/Sensitivity:

Applications:

FC

Background:

 4AM216 reacts with CD11b, a member of the integrin a chain family with 165 kDa MW. which is expressed on NK cells, monocytes, granulocytes and subsets of T and B cells. It associates with CD18 to form CD11b/CD18 complex .The cellular function of CD11b is on neutrophil and monocyte interactions with stimulated endothelium; Phagocytosis of iC3b or IgG coated particles as a receptor; Chemotaxis and apoptosis.

* CD11b is absent in Leukocyte Adhesion Deficiency (LAD-1) patients who have major problems with bacterial infections.

This clone is cross reactive with non-human primate.

 

1. Ling NR  et al., eds. (1987) Leucocyte Typing  III : White Cell Differentiation Antigens, Oxford University Press, New York. 303-334

2. Petty HR nd Todd RF. (1996) Immunol. Today 17:209

3. Springer TA (1994) Cell 76:301

4. Stewart M et al (1995) Curr Opin Cell Biol 7:690

References:

appl_detail:

Vol.per.Test: 10 μl/Test

Notice: This reagent has been pre-diluted for use at recommended volume per test in flow cytometry analysis. Typically add 10ul of this reagent to 100μl of experimental sample with 1 X 106 cells per test. Please refer to the detailed protocol when you perform a test.

Datasheet PDF