MAPKAPK5 Antibody

Catalog Number:

40313

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q8IW41
Gene Accssion:BC041049

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Fusion protein corresponding to residues near the C terminal of human mitogen-activated protein kinase-activated protein kinase 5

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MAPKAPK5 protein.

Applications:

IHC

Background:

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.

References:

appl_detail:

Immunohistochemistry:1:30-1:150

Datasheet PDF