TXNIP Antibody

Catalog Number:

40274

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9H3M7
Gene Accssion:NP_006463

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide of human thioredoxin interacting protein

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TXNIP protein.

Applications:

IHC

Background:

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

References:

appl_detail:

Immunohistochemistry:1:30-1:150

Datasheet PDF