F2 Antibody

Catalog Number:

40244

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P00734
Gene Accssion:NP_000497

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human coagulation factor II (thrombin)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total F2 protein.

Applications:

IHC

Background:

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

References:

appl_detail:

Immunohistochemistry:1:20-1:100

Datasheet PDF