TCEB3 Antibody

Catalog Number:

40239

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q14241
Gene Accssion:NP_003189

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to a region derived from internal residues of human transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TCEB3 protein.

Applications:

IHC

Background:

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.?

References:

appl_detail:

Immunohistochemistry:1:25-1:100

Datasheet PDF