SLC17A1 Antibody

Catalog Number:

40216

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q14916
Gene Accssion:NP_005065

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the C terminal of human solute carrier family 17 (organic anion transporter), member 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SLC17A1 protein.

Applications:

WB

Background:

NPT1, also called sodium-dependent phosphate transport protein, belongs to the organic anion transporter family, SLC17A. It is mainly expressed in the kidney transporting small organic anions such as PAH (para-aminohippurate), but it is also found in the liver and brain. NTP1 localizes to the apical membrane of renal proximal tubular cells and functions as a voltage driven organic anion/Cl-exchanger. It also plays a role in maintaining phosphate homeostasis. The expression of NPT1 is transcriptionally regulated by HNF-1? and HNF-3¡Ò. Indomethacin and salicylate inhibit NPT1-mediated PAH transport.

References:

appl_detail:

Western blotting: 1:200-1:1000

Datasheet PDF