LZTS1 Antibody

Catalog Number:

40201

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9Y250
Gene Accssion:NP_066300

Form of Antibody:

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Storage/Stability:

Immunogen:

Synthetic peptide corresponding to residues near the N terminal of human leucine zipper, putative tumor suppressor 1

Purification:

Antigen affinity purification.

Specificity/Sensitivity:

The antibody detects endogenous levels of total LZTS1 protein.

Applications:

IHC

Background:

This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. This gene is located on chromosomal region 8p22. Loss of heterozygosity (LOH) in the 8p arm is a common characteristic of many types of cancer.

References:

appl_detail:

Immunohistochemistry:1:10-1:50

Datasheet PDF